Light control of biological systems.
We design small molecules, peptides, and proteins that can be controlled by light.
Engineering light switchable proteins
Nature provides a treasure trove of photoswitchable proteins that are reactive to different wavelengths of light. Our lab works to develop new optogenetic tools by engineering photoswitchable proteins for applications in basic research in cell and neurobiology. In doing so, we gain fundamental knowledge about protein conformation, folding, and dynamics. Click below to learn more about our exciting research in photoswitchable protein engineering.
Photopharmacology
Bioactive small molecules that respond to light can act as photopharmaceuticals - drugs and molecular probe with that can be externally controlled by pulses of light. To learn more about exciting developments in small molecule photoswitches such as colour tuning of azobenzenes, and applications in vivo click below:
Chemistry @ University of Toronto
Our department has advanced research facilities, strong support staff, and extensive connections to the large Toronto biomolecular research hub. Aside from research support, we have social supports of all kinds: an active grad students Chem Club, the WICTO group that promotes inclusivity of all kinds, the Family Care Office that provides support for students and fellows with children, the International Office, the Health and Wellness Centre at Student Life, and First Nations House.
The group
The Woolley Lab, seen here hosting the 2024 Protein Engineering Canada Conference.